منابع مشابه
Mismatch repair outside of replication
© 2012 Landes Bioscience This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits distribution, public display, and publicly performance, making multiple copies, distribution of derivative works, provided the original work is properly cited. This license requ...
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متن کاملEukaryotic Mismatch Repair in Relation to DNA Replication.
Three processes act in series to accurately replicate the eukaryotic nuclear genome. The major replicative DNA polymerases strongly prevent mismatch formation, occasional mismatches that do form are proofread during replication, and rare mismatches that escape proofreading are corrected by mismatch repair (MMR). This review focuses on MMR in light of increasing knowledge about nuclear DNA repli...
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The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform lagging strand replication. The fact that these polymerases differ in fidelity and error specificity is interesting in light of the fact that the s...
متن کاملDNA replication and mismatch repair safeguard against metabolic imbalances.
During DNA replication, the major DNA replicative polymerases Polδ and Pole introduce noncomplementary nucleotides approximately once in every 100,000 polymerization events. Proofreading properties of these polymerases improve their fidelity by 10to 100-fold, and postreplicative DNA mismatch repair (MMR), which acts as a spell checker to remove mismatches that escape polymerase proofreading, im...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.21259